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Promethazine may cause other side effects. Box of 1000 NDC 0713-0536-10 Promethazine comes as a tablet and syrup (liquid) to take by mouth and as a suppository to use rectally.When promethazine is used to treat allergies, it is usually taken one to four times daily, before meals and/or at bedtime. June 14, 2022. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Promethazine can cause side effects. Pre- or postoperative use: 25 to 50 mg IM or IV once Citations, PRECAUTIONS- Information for Patients and Drug Interactions, Carcinogenesis, Mutagenesis, Impairment of Fertility, Report Adverse Antiemetic therapy in postoperative patients. 8-PROMCPLNC1 Iss. It should be used with caution in persons with seizure disorders or in persons who are using concomitant medications, such as narcotics or local anesthetics, which may also affect seizure threshold. The concomitant use of alcohol or other central nervous system depressants, including narcotic analgesics, sedatives, hypnotics, and tranquilizers, may have an additive effect and should be avoided or their dosage reduced. 1990 Apr;38(4):1027-31. doi: 10.1248/cpb.38.1027. Follow all instructions closely. The American Society of Health-System Pharmacists, Inc. represents that the information provided hereunder was formulated with a reasonable standard of care, and in conformity with professional standards in the field. This medicine may cause the results of some pregnancy tests to be wrong. Do not freeze the oral liquid. PROMETHAZINE HCL SUPPOSITORIES ARE CONTRAINDICATED FOR USE IN PEDIATRIC PATIENTS LESS THAN TWO YEARS OF AGE (see WARNINGS-Black Box Warning and Use in Pediatric Patients). Note that any depressant effects of promethazine HCl are not reversed by naloxone. PROMETHAZINE HYDROCHLORIDE SUPPOSITORIES, USP Ask the doctor or pharmacist if you are not sure. Promethazine HCl is a racemic compound; the empirical formula is C Do not give this medicine (promethazine suppositories) to a child who is throwing up for an unknown reason. Careers. Accessibility Subcutaneous administration is contraindicated. PMC The concomitant use of alcohol or other central nervous system depressants, including narcotic analgesics, sedatives, hypnotics, and tranquilizers, may have an additive effect and should be avoided or their dosage reduced. . WebPhenadoz Suppositories are for rectal administration only. Be ready to tell or show what was DailyMed Oral or Rectal: 1.1 mg/kg orally or rectally every 4 to 6 hours as needed, 2 years and older: In the in vivo experiments, the plasma indomethacin levels after administration of suppositories stored at different temperatures were measured in conscious and anesthetized rats. Promethazine HCl Suppositories are for rectal administration only. Files, Presentations 2 0 obj There are no adequate and well-controlled studies of Promethazine HCl Suppositories in pregnant women. PROMETHAZINE HYDROCHLORIDE Promethazine may cause breathing to slow or stop, and may cause death in children. Would you like email updates of new search results? Do not Paradoxical Reactions Check with your If you are allergic to this medicine (promethazine suppositories); any part of this medicine (promethazine suppositories); or any other drugs, foods, or substances. Allergic conjunctivitis due to inhalant allergens and foods. Antihistamines are contraindicated for use in the treatment of lower respiratory tract symptoms including asthma. Subsequent doses on succeeding days of travel should be given on rising and again before the evening meal. J Pharm Pharmacol. Duplication for commercial use must be authorized by ASHP. If you become pregnant while taking promethazine, call your doctor. Phenergan (Promethazine HCl) Suppositories are for rectal administration only. If you experience any of the following symptoms, call your doctor immediately: If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online ( Keep all drugs out of the reach of children and pets. Teratogenic Effects - Pregnancy Category C Generic name: Promethazine Suppositories [proe-METH-a-zeen] Put suppository into the rectum with gentle pressure, pointed end first. suppository. Promethazine helps control symptoms, but will not treat the cause of the symptoms or speed recovery. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. 1972 Dec;24:Suppl:133P-134. The photolytic degradation of promethazine hydrochloride does not follow simple first-order kinetics. 2 SHCl and its molecular weight is 320.88. For sedation and relief of apprehension and to produce light sleep from which the patient can be easily aroused, Preoperative, postoperative, and obstetric (during labor) sedation, Oral and Rectal: 25 mg orally, or rectally once, then 12.5 to 25 mg every 4 to 6 hours as needed, Parenteral: 12.5 to 25 mg IM or IV every 4 hours as needed, Initial day: 25 mg orally or rectally 30 to 60 minutes before traveling, then 8 to 12 hours as needed, Succeeding days of travel: 25 mg orally or rectally upon rising, with the dose repeated before the evening meal. Single 25-mg doses at bedtime or 6.25 to 12.5 mg taken three times daily will usually suffice. Presence in Breast Milk, Medline Plus, Dosage must be individualized. Chem Pharm Bull (Tokyo). Therapy adjunctive to meperidine or other analgesics for control of postoperative pain. The https:// ensures that you are connecting to the Allergic conjunctivitis due to inhalant allergens and foods, Amelioration of allergic reactions to blood or plasma, In anaphylaxis as an adjunct to epinephrine and other standard measures after the acute symptoms have been controlled, Mild, uncomplicated allergic skin manifestations of urticaria and angioedema, Other uncomplicated allergic condition of the immediate type when oral therapy is impossible or contraindicated, Early stages of labor: 50 mg IM or IV once, Nighttime sedation: 25 to 50 mg IM or IV once.